Expression data to the study: Long non-coding RNAs in hypoxia and oxidative stress - novel insights investigating a piglet model of perinatal asphyxia.

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Baumbusch, Lars Oliver, 2023, "Expression data to the study: Long non-coding RNAs in hypoxia and oxidative stress - novel insights investigating a piglet model of perinatal asphyxia.", https://doi.org/10.18710/JIQKEU, DataverseNO, V1
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Description
A total of 42 newborn piglets were randomized into four study arms: 1. hypoxia-normoxic reoxygenation, 2. hypoxia-3 minutes of hyperoxic reoxygenation, 3. hypoxia-30 minutes of hyperoxic reoxygenation, and 4. sham-operated controls. Expression of the lncRNAs BDNF-AS, H19, MALAT1, ANRIL, TUG1, PANDA and related target genes VEGFA, BDNF, TP53, HIF1alpha, and TNFalpha were assessed in cortex, hippocampus, white matter, and cerebellum by qPCR and Droplet Digital PCR (ddPCR). (2023-03-06)
The overall aim of this study was to explore the lncRNAs expression changes involved in the regulation of the oxidative stress response in perinatal asphyxia using a piglet model. Our results of different brain regions exhibited that the exposure to hypoxia causes significant alteration of expression in various lncRNAs, mainly in the cortex and hippocampus. Even a short exposure to 100% oxygen for 3 minutes caused expression changes in the lncRNAs, providing further evidence for oxidative brain injury caused by hyperoxic reoxygenation in newborns. (2023-03-06)
Subject Medicine, Health and Life Sciences
Keyword long non-coding RNA expression, mRNA expression, piglet model, perinatal asphyxia, oxidative stress
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